Educational Resources About RYBREVANT FASPRO™ and RYBREVANT® (amivantamab-vmjw)

Recently, combination treatments for EGFR-mutated mNSCLC have entered the treatment landscape, including RYBREVANT FASPRO™ + LAZCLUZE® (lazertinib) and other RYBREVANT®-based regimens.1,2 Explore this page to learn more about why you and your patients should consider RYBREVANT FASPRO™ + LAZCLUZE®.

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Clinical Crosstalk: Expert conversations on how RYBREVANT FASPRO™ + LAZCLUZE® (lazertinib) may impact patient outcomes and what this means for your practice.

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EGFR, epidermal growth factor receptor; mNSCLC, metastatic non–small cell lung cancer.

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RYBREVANT <em>FASPRO</em>™ + LAZCLUZE®: Advancing Care for EGFR+* Locally Advanced or Metastatic NSCLC videoRYBREVANT <em>FASPRO</em>™ + LAZCLUZE®: Advancing Care for EGFR+* Locally Advanced or Metastatic NSCLC video
Proactive Management of Dermatologic Adverse Reactions for a First-Line Treatment Option for EGFR+* Locally Advanced or Metastatic NSCLC with Amanda Edmond, PA-C videoProactive Management of Dermatologic Adverse Reactions for a First-Line Treatment Option for EGFR+* Locally Advanced or Metastatic NSCLC with Amanda Edmond, PA-C video

In Your Practice

Managing EGFR+ NSCLC is a complex journey. Understanding and addressing unmet needs in the treatment landscape can help you and your patients with 1L treatment and throughout the course of care.

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25% to 40% of patients on EGFR TKI monotherapy never receive 2L therapy9-11*

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Resistance to EGFR TKIs in the current treatment landscape is inevitable2†

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For further information about RYBREVANT FASPRO™ and RYBREVANT®-based regimens, talk with a J&J specialist

*Range includes patients who died or discontinued the assigned therapy without receiving 2L therapy during follow-up.9-11

†EGFR mutations and MET amplification are the most common mechanisms of resistance among patients taking EGFR TKIs.4-6

2L, second-line; AR, adverse reaction; MET, mesenchymal-epithelial transition; PFS, progression-free survival; TKI, tyrosine kinase inhibitor.

References:

  1. RYBREVANT FASPRO™ [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.
  2. Zhou F, Guo H, Xia Y, et al. The changing treatment landscape of EGFR-mutant non-small-cell lung cancer. Nat Rev Clin Oncol. 2025;22(2):95-116. doi:10.1038/s41571-024-00971-2
  3. Bazhenova L, Minchom A, Viteri S, et al. Comparative clinical outcomes for patients with advanced NSCLC harboring EGFR exon 20 insertion mutations and common EGFR mutations. Lung Cancer. 2021;162:154-161. doi:10.1016/j.lungcan.2021.10.020
  4. Passaro A, Jänne PA, Mok T, Peters S. Overcoming therapy resistance in EGFR-mutant lung cancer. Nat Cancer. 2021;2(4):377-391. doi:10.1038/s43018-021-00195-8
  5. Fu K, Xie F, Wang F, Fu L. Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance. J Hematol Oncol. 2022;15(1):173. doi:10.1186/s13045-022-01391-4
  6. Yu HA, Kerr K, Rolfo CD, et al. Detection of MET amplification (METamp) in patients with EGFR mutant (m) NSCLC after first-line (1L) osimertinib. J Clin Oncol. 2023;41(16 suppl):9074.
  7. Yang JC, Lu S, Hayashi H, et al; MARIPOSA Investigators. Overall survival with amivantamab-lazertinib in EGFR-mutated advanced NSCLC. N Engl J Med. 2025;393(17):1681-1693. doi:10.1056/NEJMoa2503001
  8. Cho BC, Li W, Spira AI, et al. Enhanced versus standard dermatologic management with amivantamab-lazertinib in EGFR-mutated advanced NSCLC: the COCOON global randomized controlled trial. J Thorac Oncol. 2025:S1556-0864(25)00939-6. doi:10.1016/j.jtho.2025.07.117
  9. Nieva J, Karia PS, Okhuoya P, et al. A real-world (rw) observational study of long-term survival (LTS) and treatment patterns after first-line (1L) osimertinib in patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive (m) advanced non-small cell lung cancer [ESMO abstract 1344P]. Ann Oncol. 2023;34(suppl 2):S774.
  10. Lee JY, Mai V, Garcia M, et al. Treatment patterns and outcomes of first-line osimertinib-treated advanced EGFR mutated NSCLC patients: a real-world study [IASLC abstract EP08.02-082]. Presented at: IASLC 2022 World Conference on Lung Cancer; August 6-9, 2022; Vienna, Austria.
  11. Girard N, Leighl NB, Ohe Y, et al. Mortality among EGFR-mutated advanced NSCLC patients after starting frontline osimertinib treatment: a real-world, US attrition analysis. Presented at: the European Lung Cancer Congress; March 29-April 1, 2023; Copenhagen, Denmark. Poster 19P.
  12. Hayashi H, Besse B, Lee S-H, et al. Mechanisms of acquired resistance to first-line amivantamab plus lazertinib vs osimertinib: updated analysis from MARIPOSA. Presented at: IASLC 2025 World Conference on Lung Cancer; September 6-9, 2025; Barcelona, Spain.
  13. Spira AI, Paz-Ares L, Han JY, et al. Preventing infusion-related reactions with intravenous amivantamab–results from SKIPPirr, a phase 2 study: a brief report. J Thorac Oncol. 2025;20(6):809-816. doi:10.1016/j.jtho.2025.01.018