ENGINEERED FOR A CHALLENGING LANDSCAPE

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In the world of EGFR+ mNSCLC, few challenges have been tougher to navigate than EGFR exon 20 insertion mutations.1-10

Until RYBREVANT®—the first and only bispecific antibody built for the treatment of adult patients with locally advanced or mNSCLC with EGFR exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or after platinum-based chemotherapy.11

Explore study results

Discover how RYBREVANT® 
may benefit your patients

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EGFR Exon 20 Insertion Mutations

Learn about EGFR exon 20
insertion mutations.

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Mechanism of Action

See how RYBREVANT® works.

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Efficacy

Explore the results from the
CHRYSALIS trial.

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Safety

Review the safety profile
of RYBREVANT®.

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Dosing Guidelines

See the recommended dosage,
preparation and administration,
and dose modification information.

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Resources & Support

Support for you and your
patients throughout their
treatment journey.

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EGFR, epidermal growth factor receptor; FDA, Food and Drug Administration; mNSCLC, metastatic non-small cell lung cancer.

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References

1. Clinical Test Report: Oncomine™ Dx Target Test US. Thermo Fisher Scientific. Accessed October 18, 2021. https://tools.thermofisher.com/content/sfs/brochures/oncomine-dx-target-test-sample-report.pdf

2. Chiang AC, Fernandes AW, Pavilack M, et al. EGFR mutation testing and treatment decisions in patients progressing on first- or second-generation epidermal growth factor receptor tyrosine kinase inhibitors. BMC Cancer. 2020;20(1):356. doi:10.1186/s12885-020-06826-0

3. Robichaux JP, Elamin YY, Tan Z, et al. Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer. Nat Med. 2018;24(5):638-646. doi:10.1038/s41591-018-0007-9

4. Riess JW, Gandara DR, Frampton GM, et al. Diverse EGFR exon 20 insertions and co-occurring molecular alterations identified by comprehensive genomic profiling of NSCLC. J Thorac Oncol. 2018;13(10):1560-1568. doi:10.1016/j.jtho.2018.06.019

5. FoundationOne®CDx. Technical specifications. Foundation Medicine. Accessed February 6, 2021. https://assets.ctfassets.net/w98cd481qyp0/YqqKHaqQmFeqc5ueQk48w/0a34fcdaa3a71dbe460cdcb01cebe8ad/F1CDx_Technical_Specifications_072020.pdf

6. Arcila ME, Nafa K, Chaft JE, et al. EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics. Mol Cancer Ther. 2013;12(2):220-229. doi:10.1158/1535-7163.MCT-12.0620

7. Oxnard GR, Lo PC, Nishino M, et al. Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions. J Thorac Oncol. 2013;8(2):179-184. doi:10.1097/JTO.0b013e3182779d18

8. Naidoo J, Sima C, Rodriguez K, et al. Epidermal growth factor receptor exon 20 insertions in advanced lung adenocarcinomas: clinical outcomes and response to erlotinib. Cancer. 2015;121(18):3212-3220. doi:10.1002/cncr.29493

9. Chen D, Song Z, Cheng G. Clinical efficacy of first-generation EGFR-TKIs in patients with advanced non-small-cell lung cancer harboring EGFR exon 20 mutations. Onco Targets Ther. 2016;9:4181-4186.

10. Girard N. Presented at: IASLC 2020 World Conference on Lung Cancer; January 28-31, 2021; Singapore.

11. RYBREVANT® [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.