Treatment with RYBREVANT® was evaluated in the CHRYSALIS trial

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CHRYSALIS is a multicenter, open-label, multicohort study that included 129 adult patients with locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations, whose disease progressed on or after platinum-based chemotherapy.1

Study Design

Efficacy was evaluated in 81 patients with locally advanced or metastatic NSCLC who had EGFR exon 20 insertion mutations as determined by prospective local testing using tissue (94%) and/or plasma (6%) samples, whose disease had progressed on or after platinum-based chemotherapy.1

Efficacy was evaluated by ORR according to Response Evaluation Criteria in Solid Tumors (RECIST v1.1) as evaluated by Blinded Independent Central Review (BICR). An additional efficacy outcome measure was duration of response (DOR) by BICR.1

Baseline Characteristics for the Efficacy Population (n=81)1
Median age 62 years (range: 42-84 years)
Female / Male 59% / 41%
Asian 49%
White 37%
Black 2.5%
Baseline body weight <80kg 74%
Adenocarcinoma 95%
Prior Immunotherapy 46%
ECOG performance status 1 67%
Median number of prior therapies 2 (range: 1-7 therapies)
Never smoked 53%
Metastatic disease 100%
Previous treatment for brain metastases 22%

ECOG, Eastern Cooperative Oncology Group.

RYBREVANT® demonstrated durable responses in the CHRYSALIS trial

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ORR in patients with EGFR exon 20 insertion mutations (n=81)1

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*According to Response Evaluation Criteria in Solid Tumors (RECIST v1.1) as evaluated by Blinded Independent Central Review (BICR).

The median DOR was 11.1 months (95% CI: 6.9, NE)1†

  • 63% of patients who responded had a DOR of ≥6 months

Based on Kaplan-Meier estimates.

BICR, Blinded Independent Central Review; CI, confidence interval; CR, complete response; DOR, duration of response; EGFR, epidermal growth factor receptor; ILD, Interstitial Lung Disease; NE, not estimable; ORR, overall response rate; PR, partial response; RECIST, Response Evaluation Criteria in Solid Tumors.

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References

1. RYBREVANT® [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.