Treatment with RYBREVANT® was evaluated in the CHRYSALIS trial

divider-mb

CHRYSALIS is a multicenter, open-label, multicohort study that included 129 adult patients with locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations, whose disease progressed on or after platinum-based chemotherapy.1

Study Design

Efficacy was evaluated in 81 patients with locally advanced or metastatic NSCLC who had EGFR exon 20 insertion mutations as determined by prospective local testing using tissue (94%) and/or plasma (6%) samples, whose disease had progressed on or after platinum-based chemotherapy.1

Efficacy was evaluated by ORR according to Response Evaluation Criteria in Solid Tumors (RECIST v1.1) as evaluated by Blinded Independent Central Review (BICR). An additional efficacy outcome measure was duration of response (DOR) by BICR.1

Baseline Characteristics for the Efficacy Population (n=81)1
Median age 62 years (range: 42-84 years)
Female / Male 59% / 41%
Asian 49%
White 37%
Black 2.5%
Baseline body weight <80kg 74%
Adenocarcinoma 95%
Prior Immunotherapy 46%
ECOG performance status 1 67%
Median number of prior therapies 2 (range: 1-7 therapies)
Never smoked 53%
Metastatic disease 100%
Previous treatment for brain metastases 22%

ECOG, Eastern Cooperative Oncology Group.

RYBREVANT® demonstrated durable responses in the CHRYSALIS trial

divider-mb

ORR in patients with EGFR exon 20 insertion mutations (n=81)1

orr-img

*According to Response Evaluation Criteria in Solid Tumors (RECIST v1.1) as evaluated by Blinded Independent Central Review (BICR).

The median DOR was 11.1 months (95% CI: 6.9, NE)1†

  • 63% of patients who responded had a DOR of ≥6 months

Based on Kaplan-Meier estimates.

 

Amivantamab-vmjw (RYBREVANT®) is recommended in the NCCN Guidelines®

divider-mb

The NCCN Guidelines recommend amivantamab-vmjw (RYBREVANT®) as a subsequent therapy option for patients with EGFR+ mNSCLC with exon 20 insertion mutations who have progressed on initial systemic therapy2‡

See the NCCN Guidelines for detailed recommendations, including other treatment options.2

BICR, Blinded Independent Central Review; CI, confidence interval; CR, complete response; DOR, duration of response; EGFR, epidermal growth factor receptor; ILD, Interstitial Lung Disease; mNSCLC, metastatic non-small cell lung cancer; NCCN, National Comprehensive Cancer Network®; NE, not estimable; ORR, overall response rate; PR, partial response; RECIST, Response Evaluation Criteria in Solid Tumors.

 

Explore

cnt-divider

moalogo

Mechanism of Action

See how RYBREVANT® works.

Learn more

safetylogo

Safety

Review the safety profile
of RYBREVANT®.

Learn more

dosinglogo

Dosing Guidelines

See the recommended dosage,
preparation and administration,
and dose modification information.

Learn more

register

Register for Updates

Sign up to receive the latest news and information about RYBREVANT® by completing the registration form.

References

1. RYBREVANT® [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.

2. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Non-Small Cell Lung Cancer V.3. 2022. © National Comprehensive Cancer Network, Inc. 2022. All rights reserved. Accessed March 16, 2022. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.