Dosing Schedule
Recommended dosing schedule for RYBREVANT® + chemotherapy1


*Dose adjustments not required for subsequent body weight changes.
†This refers only to RYBREVANT® and pemetrexed. Carboplatin should only be administered every 3 weeks for up to 12 weeks.
The recommended dosage of RYBREVANT® is based on baseline body weight and can be administered as an intravenous infusion after dilution.1
With chemotherapy
Administer the regimen in the following order: pemetrexed first, carboplatin second, and RYBREVANT® last.
Refer to the full Prescribing Information for pemetrexed and carboplatin for the respective dosing information.
For additional dosage and administration guidance for RYBREVANT® (including as a single agent), please see the full Prescribing Information.
See Proactive Therapy Management to help reduce the risk of key ARs
Learn moreIn both the MARIPOSA-2 and PAPILLON trials, infusion times decreased over time with RYBREVANT®2
MARIPOSA-2 clinical trial median infusion times by hours*


PAPILLON clinical trial median infusion times by hours†


Total infusion time is approximately 4 to 6 hours for Day 1 and 6 to 8 hours for Day 2. Day 2 chair time is longer because of increased dose from Day 1. Subsequent infusion time is approximately 2 hours.1
*Data reflect results from 3-week dosing in the MARIPOSA-2 trial.2
†Data reflect results from 3-week dosing in the PAPILLON trial.2
AR, adverse reaction; AUC, area under the curve; Q3W, once every 3 weeks.
Preparation
Preparation for RYBREVANT®1
Dilute and prepare RYBREVANT® for intravenous infusion before administration


PE, polyethylene; PP, polypropylene; PVC, polyvinylchloride.
Administration
Administration for RYBREVANT®1
- Administer the diluted solution by intravenous infusion using an infusion set fitted with a flow regulator and with an in-line, sterile, non-pyrogenic, low protein-binding PES filter (pore size 0.2 micrometer)
- Administration sets must be made of PU, PBD, PVC, PP, or PE
- The administration set with filter must be primed with either 5% dextrose injection or 0.9% sodium chloride injection prior to the initiation of each RYBREVANT® infusion
- Do not infuse RYBREVANT® concomitantly in the same intravenous line with other agents
RYBREVANT® in combination with carboplatin and pemetrexed1
- Administer RYBREVANT® in combination with carboplatin and pemetrexed infusions every 3 weeks intravenously until disease progression or unacceptable toxicity according to the infusion rates
- Administer RYBREVANT® via a peripheral line on Week 1 and Week 2 to reduce the risk of IRRs during initial treatment
- RYBREVANT® may be administered via a central line for subsequent weeks
- For the initial infusion, prepare RYBREVANT® as close to administration time as possible to allow for the possibility of extended infusion time in the event of an IRR
- Administer the pemetrexed infusion first, carboplatin infusion second, and the RYBREVANT® infusion last
IRR, infusion-related reaction; PBD, polybutadiene; PES, polyethersulfone; PU, polyurethane.


*In the absence of IRRs, increase the initial infusion rate to the subsequent infusion rate after 2 hours based on patient tolerance. Total infusion time is approximately 4 to 6 hours for Day 1 and 6 to 8 hours for Day 2. Subsequent infusion time is approximately 2 hours.
References:
- RYBREVANT® [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.
- Data on file. Janssen Biotech, Inc.